Makrothrombozytopenie Typ B
Macrothrombocytopenia (MTC)
General description
Macrothrombocytopenia (MTC) is a hereditary disorder in the formation of platelets (thrombocytes), which are an important part of blood coagulation. Affected dogs do not have a bleeding diathesis, but there is a danger of malpractice. Symptoms mentioned above could be confused with acquired thrombocytopenia, which can be triggered by infection, medication or immune reactions.
Breeds
American Cocker Spaniel, Bichon Frisé, Boxer, Cairn Terrier, Cavalier King Charles Spaniel, Chihuahua, English Cocker Spaniel, Havanese, Jack Russell Terrier, Labrador Retriever, Maltese, Miniature Poodle, Norfolk Terrier, Parson Russell Terrier, Poodle, Shih Tzu, Toy Poodle
Order details
| Test number | 8217 |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 7-14 working days |
Test specifications
Detailed description
Macrothrombocytopenia (MTC) is an inherited (congenital) disorder in the formation of blood platelets (thrombocytes), which play an important role in blood coagulation. Symptom of hereditary MTC is a reduced number of platelets (thrombocytopenia). In addition, many of the remaining platelets are enlarged. Two causing variants have been identified in the ß1-tubulin gene. Affected dogs are not prone to bleeding, but there is a risk of mistreatment, since the above signs can also be mistaken for acquired thrombocytopenia, which can be triggered by infections, medication or immune reactions, for example. The genetic test is therefore important as method of differential diagnosis, since antibiotics or corticosteroids are inappropriate to treat hereditary macrothrombocytopenia.
