Primary lens luxation (PLL)
Primary lens luxation (PLL)
General description
Dogs affected from PLL have painful glaucomas and blindness due to a dislocation of the lens due to a breakdown or disintegration of the zonula fibres. PLL can be inherited or acquired. First clinical signs of the inherited form of PLL are detectable at the very young age of 20 months. A complete lens luxation typically occurs at the age of 3 to 8 years.
Breeds
American Eskimo Dog, American Hairless Terrier, Australian Cattle Dog, Chinese Crested Dog, Danish-Swedish Farmdog, Fox Terrier, German Hunting Terrier, Italian Volpino, Jack Russell Terrier, Lakeland Terrier, Lancashire Heeler, Lucas Terrier, Miniature Bull Terrier, Norfolk Terrier, Norwich Terrier, Parson Russell Terrier, Patterdale Terrier, Pug, Rat Terrier, Sealyham Terrier, Teddy Roosevelt Terrier, Tenterfield Terrier, Tibetan Terrier, Toy Fox Terrier, Welsh Terrier, Westfalen Terrier, Yorkshire Terrier
Order details
| Test number | 8226 |
| Abbreviation | PLL |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 3-5 working days |
Test specifications
| Symptom complex | ophthalmic |
| Inheritance | autosomal recessive; the literature describes that 2-20% of PLL carriers (N/PLL) develop PLL in the course of their lives. Carriers therefore have an (albeit low) risk of developing PLL. |
| Age of onset | 3-8 years |
| Causality | causally |
| Gene | ADAMTS17 |
| Mutation | G-A |
| Literature | OMIA:000588-9615 |
Detailed description
The zonula fibres secure the position of the lens. Dogs affected from PLL have painful glaucomas and blindness due to a dislocation of the lens due to a breakdown or disintegration of the zonula fibres. PLL can be inherited or acquired. Therefore the disease might also affect genetically free dogs. First clinical signs of the inherited form of PLL are detectable at the very young age of 20 months. A complete lens luxation typically occurs at the age of 3 to 8 years.
