Familiäre Nephropathie (FN) — English Cocker Spaniel, Welsh Springer Spaniel
Familial nephropathy (FN) - English Cocker Spaniel, Welsh Springer Spaniel *
General description
The Familial or Hereditary Nephropathy (FN) is a juvenile-onset fatal kidney disease. The renal disease caused by FN invariably is progressive and ultimately fatal. Dogs with FN typically develop chronic renal failure between 6 month and 2 years of age, with eventual and sometimes rapid destruction of both kidneys. The first clinical signs are excessive water consumption, growth rate or loss in weight, reduced appetite, and vomiting.
Breeds
English Cocker Spaniel, Welsh Springer Spaniel
Order details
| Test number | 8131 |
| Abbreviation | FN |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 7-14 working days |
Test specifications
| Symptom complex | nephrological |
| Inheritance | autosomal recessive |
| Age of onset | 6 months- 2 years |
| Causality | causally |
| Gene | COL4A4 |
| Mutation | T-A |
| Literature | OMIA:002618-9615 |
Detailed description
The Familial or Hereditary nephropathy (FN) is a juvenile-onset fatal kidney disease. The renal disease caused by FN invariably is progressive and ultimately fatal. Dogs with FN typically develop chronic renal failure between 6 month and 2 years of age, with eventual and sometimes rapid destruction of both kidneys. The first clinical signs are excessive water consumption, growth rate or loss in weight, reduced appetite, and vomiting.
