Congenitaler Megaösophagus (CIM)
Congenital idiopathic megaesophagus (CIM)
General description
Congenital idiopathic megaesophagus (CIM) affected dogs show symptoms like regurgitation of meal and water because the transport of food within the stomach is hindered. A variant has been identified in this breed that is associated with an increased risk of CIM.
Breeds
German Shepherd Dog
Order details
| Test number | 8781 |
| Abbreviation | CIM |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 7-14 working days |
Test specifications
| Symptom complex | systemic |
| Causality | High-risk factor |
| Gene | MCHR2 |
| Mutation | DEL |
| Literature | OMIA:002716-9615 |
Detailed description
Congenital idiopathic megaesophagus (CIM) is characterized as a gastrointestinal motility disorder preventing the normal transport of food within the stomach by reduced peristaltic activity and dilation of the esophagus. Affected dogs show regurgitation of meal and water and therefore failing to thrive. Complications as aspiration pneumonia can occur. \nIn the breed German Shepherd, a genetic variant has been identified that is associated with an increased risk of CIM. Approximately one third of the homozygously affected female dogs showed symptoms of CIM, while as many as half of the homozygously affected male dogs showed symptoms. However, other, unknown factors play a role in the development of megaesophagus. Many of the affected dogs showed symptoms under one year of age. The genetic test enables targeted breeding to preferentially spread the non-risk allele in the breed.
