{"id":218184,"date":"2024-09-12T07:23:48","date_gmt":"2024-09-12T05:23:48","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/c3-defizienz-c3"},"modified":"2024-09-12T07:23:48","modified_gmt":"2024-09-12T05:23:48","slug":"c3-defizienz-c3","status":"publish","type":"page","link":"https:\/\/staging.laboklin.com\/labogen\/labogen_wp\/index.php\/erbkrankheiten-hund\/c3-defizienz-c3\/","title":{"rendered":"C3-Defizienz (C3)"},"content":{"rendered":"<div class=\"wrap-top\"><div class=\"wrap-left\"><h1 class=\"header-1\">C3-Defizienz (C3)<\/h1><h4><strong>General description<\/strong><\/h4><p class=\"bodytext\">Die dritte Komponente des Komplementsystems (C3) ist ein wichtiger Faktor f\u00fcr die Immunabwehr des K\u00f6rpers zur Bek\u00e4mpfung von Mikroorganismen wie Bakterien, Pilzen und Parasiten. Betroffene Hund neigen zu erh\u00f6hter Empf\u00e4nglichkeit f\u00fcr Infektionen. <\/p><h4 class=\"header-4\"><strong><span>Breeds<\/span><\/strong><\/h4><p>Bretonischer Spaniel<\/p><\/div><div class=\"wrap-right\"><div class=\"wrap-toggle\"><div class=\"toggle-details\"><details><summary class=\"summary-details\">Order details<\/summary><table border=\"0\"><tr><td width=\"45%\"><span><strong>Test number<\/strong><\/span><\/td><td>8184<\/td><\/tr><tr><td><strong>Abbreviation<\/strong><\/td><td>C3<\/td><\/tr><tr><td><strong>Sample material<\/strong><\/td><td>0,5 ml EDTA Blut, 2x Backenabstrich, 1x Spezialabstrich (eNAT)<\/td><\/tr><tr><td><strong>Test duration<\/strong><\/td><td>7-14 Werktage<\/td><\/tr><\/table><\/details><details><summary class=\"summary-specs\">Test specifications<\/summary><table border=\"0\"><tr><td width=\"45%\"><strong>Symptom complex<\/strong><\/td><td>immunologisch<\/td><\/tr><tr><td width=\"45%\"><strong>Inheritance<\/strong><\/td><td>autosomal-rezessiv<\/td><\/tr><tr><td width=\"45%\"><strong>Causality<\/strong><\/td><td>urs\u00e4chlich<\/td><\/tr><tr><td width=\"45%\"><strong>Gene<\/strong><\/td><td>C3<\/td><\/tr><tr><td width=\"45%\"><strong>Mutation<\/strong><\/td><td>DEL<\/td><\/tr><tr><td width=\"45%\"><strong>Literature<\/strong><\/td><td><a href='https:\/\/www.omia.org\/OMIA000155\/9615\/' target='_blank'>OMIA:000155-9615<\/a><\/td><\/tr><\/table><\/details><\/div><div class=\"order-now\"><strong><a href=\"https:\/\/shop.labogen.com\">Order now ...<\/a><\/strong><\/div><\/div><\/div><div class=\"clear-both\"><\/div><\/div><div class=\"wrap-detailed\"><details><summary class=\"detail-summary\">Detailed description<\/summary><p class=\"detailed\"><p>Die dritte Komponente des Komplementsystems (C3) ist ein wichtiger Faktor f\u00fcr die Immunabwehr des K\u00f6rpers zur Bek\u00e4mpfung von Mikroorganismen wie Bakterien, Pilzen und Parasiten. Die C3-Defizienz der Rasse Bretonischer Spaniel macht sich  daher als eine geschw\u00e4chte Immunabwehr bemerkbar. Eine genetische Variante im <em>C3<\/em>-Gen verhindert die vollst\u00e4ndige Bildung von C3 und unterbricht somit die Abwehrkaskade.<\/p><p> Ein h\u00e4ufiger Nebenbefund beim betroffenen Hund ist eine Erkrankung der Niere (Glomerulonephritis).<\/p><\/p><\/details>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":6261,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-218184","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/staging.laboklin.com\/labogen\/labogen_wp\/index.php\/wp-json\/wp\/v2\/pages\/218184","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.laboklin.com\/labogen\/labogen_wp\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/staging.laboklin.com\/labogen\/labogen_wp\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/staging.laboklin.com\/labogen\/labogen_wp\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.laboklin.com\/labogen\/labogen_wp\/index.php\/wp-json\/wp\/v2\/comments?post=218184"}],"version-history":[{"count":0,"href":"https:\/\/staging.laboklin.com\/labogen\/labogen_wp\/index.php\/wp-json\/wp\/v2\/pages\/218184\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/staging.laboklin.com\/labogen\/labogen_wp\/index.php\/wp-json\/wp\/v2\/pages\/6261"}],"wp:attachment":[{"href":"https:\/\/staging.laboklin.com\/labogen\/labogen_wp\/index.php\/wp-json\/wp\/v2\/media?parent=218184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}