Familiäres Schilddrüsenkarzinom (FTFC)
Familial thyroid follicular cell carcinoma (FTFC)
General description
Two genetic variants in the TPO gene have been identified, that are associated with an increased risk for the familial thyroid follicular cell carcinoma (FTFC) in the breed German Longhaired Pointer.
Breeds
German Long-haired Pointing Dog
Order details
| Test number | 8871 |
| Abbreviation | FTFC |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 7-14 working days |
Test specifications
| Symptom complex | tumor marker |
| Causality | High-risk factor |
| Gene | TPO |
| Mutation | G-A |
| Literature | OMIA:002380-9615 |
Detailed description
Two genetic variants in the TPO gene have been identified in the breed German Longhaired Pointer, that are associated with the familial thyroid follicular cell carcinoma (FTFC). Dogs with two copies of each variant or both variants have an approximately 16 times higher risk to develop FTFC compared to dogs not carrying the variants. Most of the dogs studied were over 10 years old at the time of diagnosis.
