Hyperkaliämische periodische Paralyse (HYPP)
Hyperkalemic periodic paralysis (HYPP)
General description
The disease is characterized by intermittent episodes of muscular fasciculations, weakness, myotonia, or involuntary recumbency.
Breeds
Appaloosa, Paint Horse, Quarab, Quarter Horse, Quarter pony
Order details
| Test number | 8000 |
| Abbreviation | HYPP |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 3-5 working days |
Test specifications
| Symptom complex | muscular |
| Inheritance | autosomal dominant |
| Age of onset | 3-7 years |
| Causality | causally |
| Literature | OMIA:000785-9796 |
Detailed description
Hyperkalaemic Periodic Paralysis has been reported in Quarter Horses (Offsprings of the stallion “Impressive”) and horses with Quarterhorse blood (Apaloosas and Paints). The disease is characterized by intermittent episodes of muscular fasciculations, weakness, myotonia, or involuntary recumbency. HYPP is the result of a genetic mutation in the sodium channel gene of skeletal muscles. It is inherited as an autosomal dominant trait. That means that a heterozygous carrier of the defect gene shows the same symptoms than a horse with both allels affected.
