Progressive Retinaatrophie (rcd2-PRA)
Progressive retinal atrophy (rcd2-PRA)
General description
The Progressive Retinal Atrophy(PRA) leads to a degeneration of the retina and results in blindness. Syptoms typically get more severe over time.
Breeds
Collie (rough/smooth)
Order details
| Test number | 8309 |
| Abbreviation | rcd2-PRA |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 7-14 working days |
Test specifications
| Symptom complex | ophthalmic |
| Inheritance | autosomal recessive |
| Age of onset | 6 weeks |
| Causality | causally |
| Gene | RD3 |
| Mutation | INS |
| Literature | OMIA:001260-9615 |
Detailed description
The “Collie-PRA”, also termed rod-cone dysplasia type 2 (rcd2), is one form of progressive retina degeneration which is known for a long time as major health problem in the collie breed. An abnormal development of the cones and rods of the retina leads to night blindness with early onset. First symptoms appear at whelp-age of about 6 weeks. In the majority of cases, a complete loss of vision appears till an age of 1 in rcd2-affected dogs.
